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Titleholders Real Madrid face a major hurdle in their quest for a seventh Champions League title in 12 seasons when they host Arsenal in the return leg of the quarterfinals, on Wednesday.
The Gunners lead 3-0 after the first leg in London last week.
Meanwhile, Bayern Munich face the daunting challenge of winning away at Inter Milan to book a place in the semifinals.
The Bavarian club is 2-1 down in the tie. Inter scored a late winner at Allianz Arena last week.
Meanwhile, Barcelona and Paris Saint -Germain punched their ticket to the semifinals following two gripping second leg quarterfinal ties, on Tuesday.
Serhou Guirassy scored a hat-trick as German outfit Borussia Dortmund beat Barcelona 3-1, but the Catalan club advanced 5-3 on aggregate after their 4-0 first leg win at home.
The French champions PSG also suffered defeat, they lost 3-2 to Aston Villa at Villa Park, but went through 5-4 on aggregate.
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